De Soto, Wisconsin, located in Vernon County along the Mississippi River, sits at the heart of the Driftless Region. Within a 100-mile radius, the landscape exemplifies everything that makes this area special:
To the north and east, you’ll find rolling hills and ridges near La Crosse, Viroqua, and Sparta. These areas showcase a mix of organic farms, trout streams, and winding backroads—ideal for agritourism and quiet getaways.
To the south, places like Prairie du Chien, Decorah (Iowa), and Galena (Illinois) offer a blend of riverfront history, scenic bluffs, and cultural attractions. Decorah, for example, is known for its Norwegian heritage and outdoor recreation, while Galena is famous for its preserved 19th-century architecture.
To the west, the region drops toward the Mississippi River, where steep bluffs overlook vast river valleys, floodplains, and wetlands. This stretch includes protected areas like Effigy Mounds National Monument and the Upper Mississippi River National Wildlife and Fish Refuge, both rich in cultural and natural heritage.
Overall, the area around De Soto, WI offers a striking mix of geological wonder, scenic beauty, and rural charm—making it a standout destination for boating, fishing, hunting, history buffs, nature lovers, and those seeking a unique vacation area known for its friendly Wisconsin hospitality.
